Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.77 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17783464 | 0.87 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL17783342 | 0.86 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL18901044 | 0.84 | ROCK2 (0.68) | ROCK2ROCK1 | |
| SCHEMBL16345052 | 0.82 | ROCK2 (0.66) | ROCK2METAP2 | |
| SCHEMBL18901399 | 0.82 | ROCK2 (0.79) | ROCK2ROCK1 | |
| SCHEMBL17783685 | 0.81 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL17783683 | 0.81 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL18901199 | 0.80 | ROCK2 (0.69) | ROCK2 | |
| SCHEMBL16377373 | 0.78 | ROCK2 (0.64) | ROCK2METAP2 | |
| SCHEMBL17783589 | 0.76 | ROCK2 (1.00) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016951-B1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-05-31 | — | — | EP | disclosed |