Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 1/20 | 0.46 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL899509 | 0.88 | USP28 (0.43) | USP28USP25CHRNB2CHRNA4ADRB2 | |
| SCHEMBL12073832 | 0.84 | USP28 (0.42) | USP28USP25CHRNB2CHRNA4ADRB2 | |
| SCHEMBL18902025 | 0.84 | MEN1 (0.40) | USP28USP25CHRNB2CHRNA4TAAR1 | |
| Hydrochloric Acid SCHEMBL14935758 | 0.83 | USP28 (0.42) | USP28USP25CHRNB2CHRNA4ADRB2 | |
| Hydrochloric Acid SCHEMBL14935757 | 0.83 | USP28 (0.42) | USP28USP25CHRNB2CHRNA4ADRB2 | |
| SCHEMBL18902116 | 0.83 | TAAR1 (0.38) | USP28USP25CHRNB2CHRNA4TAAR1 | |
| Hydrochloric Acid SCHEMBL5592375 | 0.82 | USP28 (0.49) | USP28USP25CHRNB2CHRNA4HTR1A | |
| SCHEMBL18901972 | 0.82 | HRH4 (0.41) | USP28USP25 | |
| SCHEMBL12074167 | 0.81 | TRPV1 (0.41) | USP28USP25CHRNB2CHRNA4ADRB2 | |
| Hydrochloric Acid SCHEMBL14935784 | 0.80 | TRPV1 (0.40) | USP28USP25CHRNB2CHRNA4ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3173411-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | Purdue Pharma L.P. (US) | 2017-05-31 | — | — | EP | disclosed |