Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL883168 | 1.00 | KMT2A (0.41) | KMT2AMAPTNPC1RAB9AHPGD | |
| SCHEMBL12333081 | 0.97 | KMT2A (0.40) | KMT2AMAPTNPC1RAB9AHPGD | |
| SCHEMBL12686973 | 0.91 | NPC1 (0.41) | KMT2ANPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL1293820 | 0.90 | ALDH1A1 (0.36) | KMT2AMAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL883147 | 0.85 | KMT2A (0.41) | KMT2AMAPTNPC1RAB9AHPGD | |
| SCHEMBL1294457 | 0.84 | NPC1 (0.36) | NPC1RAB9AL3MBTL1 | |
| SCHEMBL1294688 | 0.84 | NPC1 (0.36) | NPC1RAB9AL3MBTL1 | |
| SCHEMBL12686982 | 0.84 | USP30 (0.50) | NPC1RAB9AALDH1A1 | |
| SCHEMBL18901586 | 0.84 | USP30 (0.50) | NPC1RAB9AALDH1A1 | |
| SCHEMBL1294687 | 0.84 | NPC1 (0.36) | NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2912031-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-05-31 | — | — | EP | disclosed |