Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9999353 | 0.90 | GPR119 (0.46) | GPR119DPP4KITCKS1BSKP1 | |
| SCHEMBL12074313 | 0.90 | GPR119 (0.46) | GPR119DPP4KITCKS1BSKP1 | |
| SCHEMBL12074543 | 0.90 | GPR119 (0.46) | GPR119DPP4KITCKS1BSKP1 | |
| SCHEMBL9999006 | 0.83 | GPR119 (0.48) | GPR119KITCKS1BSKP1SKP2 | |
| SCHEMBL30893588 | 0.82 | GPR119 (0.52) | GPR119KITCKS1BSKP1SKP2 | |
| SCHEMBL2420435 | 0.82 | GPR119 (0.52) | GPR119KITCKS1BSKP1SKP2 | |
| SCHEMBL16210187 | 0.82 | TRPV1 (0.53) | GPR119KITCKS1BSKP1SKP2 | |
| SCHEMBL24125815 | 0.81 | GPR119 (0.51) | GPR119KITCKS1BSKP1SKP2 | |
| SCHEMBL21551198 | 0.81 | GPR119 (0.54) | GPR119KITCKS1BSKP1SKP2 | |
| SCHEMBL30931849 | 0.81 | GPR119 (0.54) | GPR119KITCKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3173411-B1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | PURDUE PHARMA LP (US) | 2018-05-09 | — | — | EP | disclosed |
| EP-3173411-A1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | Purdue Pharma L.P. (US) | 2017-05-31 | — | — | EP | disclosed |