Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18902179 | 0.89 | KCNH2 (0.52) | KCNH2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL18902194 | 0.84 | KCNH2 (0.59) | KCNH2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL18902234 | 0.83 | KCNH2 (0.46) | KCNH2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL17018790 | 0.81 | KCNH2 (0.54) | KCNH2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL17018788 | 0.79 | KCNH2 (0.53) | KCNH2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL19902113 | 0.79 | KCNH2 (0.47) | KCNH2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL19807401 | 0.76 | KCNH2 (0.71) | KCNH2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL18012600 | 0.76 | KCNH2 (0.71) | KCNH2CYP3A4CYP2C9CYP2C19MEN1 | |
| Hydrochloric Acid SCHEMBL17969205 | 0.75 | KCNH2 (0.71) | KCNH2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL18902224 | 0.74 | KMT2A (0.51) | KCNH2CYP3A4CYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900674-B1 | COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2017-05-31 | — | — | EP | disclosed |