Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17018790 | 0.84 | KCNH2 (0.54) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL17018788 | 0.82 | KCNH2 (0.53) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL18902174 | 0.79 | KCNH2 (0.49) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL17018791 | 0.76 | KCNH2 (0.58) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL16961226 | 0.75 | KCNH2 (0.72) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL19807401 | 0.74 | KCNH2 (0.71) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL18012600 | 0.74 | KCNH2 (0.71) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| Hydrochloric Acid SCHEMBL17006410 | 0.74 | KCNH2 (0.73) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| SCHEMBL19807539 | 0.74 | KCNH2 (0.56) | KCNH2CYP3A4CYP2C9CYP2C19TNIK | |
| Hydrochloric Acid SCHEMBL17969205 | 0.73 | KCNH2 (0.71) | KCNH2CYP3A4CYP2C9CYP2C19TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902738-B2 | Compounds and methods for preventing, treating and/or protecting against sensory hair cell death | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2018-02-27 | — | — | US | disclosed |