Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 11/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | ATM | Q13315 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453561 | 0.89 | KCNH2 (0.61) | KCNH2KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL5453554 | 0.89 | KCNH2 (0.61) | KCNH2KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL17022020 | 0.87 | KCNH2 (0.79) | KCNH2KMT2AKDM4ENPSR1ALDH1A1 | |
| SCHEMBL17021989 | 0.86 | KCNH2 (0.72) | KCNH2KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL2682306 | 0.86 | KCNH2 (1.00) | KCNH2KMT2AKDM4ENPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL17006318 | 0.86 | KCNH2 (0.79) | KCNH2KMT2AKDM4ENPSR1ALDH1A1 | |
| SCHEMBL17022007 | 0.86 | KCNH2 (0.66) | KCNH2KMT2AKDM4ENPSR1ALDH1A1 | |
| SCHEMBL16961281 | 0.86 | KCNH2 (0.71) | KCNH2KMT2AKDM4ENPSR1ALDH1A1 | |
| SCHEMBL17021978 | 0.85 | KCNH2 (0.80) | KCNH2KMT2AKDM4ENPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL16961428 | 0.85 | KCNH2 (0.72) | KCNH2KMT2AKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900674-B1 | COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2017-05-31 | — | — | EP | disclosed |