Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 15/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18904137 | 0.88 | PKM (0.82) | PKMKDM4EALDH1A1LMNAGAA | |
| SCHEMBL12881761 | 0.87 | PKM (1.00) | PKMKDM4EALDH1A1LMNAGAA | |
| SCHEMBL12158236 | 0.85 | PKM (1.00) | PKMKDM4EALDH1A1LMNAGAA | |
| SCHEMBL1684648 | 0.85 | PKM (0.82) | PKMKDM4EALDH1A1LMNAGAA | |
| SCHEMBL5026658 | 0.85 | PKM (0.82) | PKMKDM4EALDH1A1LMNAGAA | |
| SCHEMBL25349301 | 0.85 | PKM (0.82) | PKMKDM4EALDH1A1LMNAGAA | |
| SCHEMBL5023468 | 0.85 | PKM (0.82) | PKMKDM4EALDH1A1LMNAGAA | |
| SCHEMBL12158235 | 0.85 | PKM (0.77) | PKMALDH1A1LMNAGAAMAPT | |
| Bromide SCHEMBL18040709 | 0.84 | PKM (0.80) | PKMKDM4EALDH1A1LMNAGAA | |
| SCHEMBL12789925 | 0.84 | PKM (0.66) | PKMKDM4EALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926719-B1 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-31 | — | — | EP | disclosed |