Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 4/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.38 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.38 |
| ▸ | HSD17B13 | Q7Z5P4 | 6/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL283372 | 0.79 | CRBN (0.64) | DDB1CRBNIKZF3 | |
| SCHEMBL18945874 | 0.79 | CRBN (0.64) | DDB1CRBNIKZF3 | |
| SCHEMBL16587068 | 0.78 | CLK1 (0.46) | HSD17B13PARP1 | |
| SCHEMBL16768177 | 0.77 | DDB1 (0.49) | DDB1CRBNIKZF3HSD17B13PARP1 | |
| SCHEMBL30417848 | 0.74 | IDO1 (0.43) | HSD17B13PARP1PIK3CDPIK3CG | |
| SCHEMBL30419567 | 0.73 | HSD17B13 (0.47) | HSD17B13PARP1PIK3CDPIK3CGPIK3CB | |
| SCHEMBL30956576 | 0.69 | HSD17B13 (0.54) | HSD17B13PARP1 | |
| SCHEMBL4531330 | 0.69 | PIK3CD (0.45) | PARP1PIK3CD | |
| SCHEMBL30418480 | 0.68 | HSD17B13 (0.43) | HSD17B13PARP1 | |
| SCHEMBL30418923 | 0.68 | IDO1 (0.43) | HSD17B13PARP1PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420498-B1 | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORP (US) | 2017-05-31 | — | — | EP | disclosed |