Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP2 | P42575 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18908683 | 0.98 | KMT2A (0.47) | CASP2KMT2AMEN1SMN1; SMN2TP53 | |
| SCHEMBL18908733 | 0.98 | KMT2A (0.47) | CASP2KMT2AMEN1SMN1; SMN2TP53 | |
| SCHEMBL22054925 | 0.98 | KMT2A (0.47) | CASP2KMT2AMEN1SMN1; SMN2TP53 | |
| SCHEMBL16674452 | 0.89 | KMT2A (0.47) | KMT2AMEN1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL16674308 | 0.89 | KMT2A (0.53) | KMT2AMEN1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL17833969 | 0.88 | KMT2A (0.50) | KMT2AMEN1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL23665082 | 0.87 | KMT2A (0.57) | KMT2AMEN1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL22054928 | 0.87 | KMT2A (0.57) | KMT2AMEN1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL18908729 | 0.87 | KMT2A (0.57) | KMT2AMEN1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL18908667 | 0.87 | KMT2A (0.57) | KMT2AMEN1SMN1; SMN2TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017091673-A2 | BIVALENT BROMODOMAIN INHIBTORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-06-01 | — | — | WO | disclosed |