Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CASP2 | P42575 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA4 | P22748 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.37 |
| ▸ | GLP1R | P43220 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18908733 | 1.00 | KMT2A (0.47) | KMT2AMEN1CASP2TP53SMN1; SMN2 | |
| SCHEMBL22054925 | 1.00 | KMT2A (0.47) | KMT2AMEN1CASP2TP53SMN1; SMN2 | |
| SCHEMBL18908670 | 0.98 | CASP2 (0.46) | KMT2AMEN1CASP2TP53SMN1; SMN2 | |
| SCHEMBL17833969 | 0.90 | KMT2A (0.50) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL23665082 | 0.89 | KMT2A (0.57) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL22054928 | 0.89 | KMT2A (0.57) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL18908667 | 0.89 | KMT2A (0.57) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL18908729 | 0.89 | KMT2A (0.57) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL16674452 | 0.88 | KMT2A (0.47) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL23567384 | 0.88 | FAAH (0.51) | KMT2AMEN1CASP2GLP1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017091673-A2 | BIVALENT BROMODOMAIN INHIBTORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-06-01 | — | — | WO | disclosed |