Sugi Predict

Sugi Predict / Compounds / SCHEMBL1890868

SCHEMBL1890868

SCHEMBL1890868

CC1(C)CN(S(=O)(=O)c2cc(F)cc(F)c2)Cc2c(NC(=O)c3ccc(N4CC(O)C4)cc3NC3CCOCC3)n[nH]c21

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ INSR P06213 14/20 0.48
▸ ALK Q9UM73 14/20 0.48
▸ IGF1R P08069 14/20 0.48
▸ NTRK1 P04629 4/20 0.47
▸ NTRK3 Q16288 4/20 0.47
▸ NTRK2 Q16620 4/20 0.47
▸ AURKA O14965 2/20 0.47
▸ AURKB Q96GD4 2/20 0.47
▸ PLK4 O00444 1/20 0.47
▸ DAPK3 O43293 1/20 0.47
▸ JAK2 O60674 1/20 0.47
▸ MAP4K4 O95819 1/20 0.47
▸ ABL1 P00519 1/20 0.47
▸ PRKCG P05129 1/20 0.47
▸ LCK P06239 1/20 0.47
▸ FYN P06241 1/20 0.47
▸ CSF1R P07333 1/20 0.47
▸ LYN P07948 1/20 0.47
▸ RET P07949 1/20 0.47
▸ MET P08581 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1889556 0.95 INSR (0.48) INSRALKIGF1RNTRK1NTRK3
SCHEMBL1886641 0.93 INSR (0.52) INSRALKIGF1RNTRK1NTRK3
SCHEMBL1892272 0.92 INSR (0.58) INSRALKIGF1RNTRK1NTRK3
SCHEMBL1888371 0.92 INSR (0.58) INSRALKIGF1RNTRK1NTRK3
SCHEMBL1886578 0.91 INSR (0.47) INSRALKIGF1RNTRK1NTRK3
SCHEMBL1885378 0.90 INSR (0.52) INSRALKIGF1RNTRK1NTRK3
SCHEMBL1884747 0.90 INSR (0.53) INSRALKIGF1RNTRK1NTRK3
SCHEMBL1889035 0.90 IGF1R (0.51) INSRALKIGF1RNTRK1NTRK3
SCHEMBL1884228 0.89 INSR (0.48) INSRALKIGF1RNTRK1NTRK3
SCHEMBL1893607 0.89 INSR (0.53) INSRALKIGF1RNTRK1NTRK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8173659-B2 Substituted pyrazolo[4,3-C]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2012-05-08 — — US disclosed
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-09-22 — — US disclosed
US-7947686-B2 Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-24 — — US disclosed
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-01-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS MAP3K3, MAP3K1, MAP3K19 INSR 922/4885ALK 517/4885IGF1R 760/4885
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors MAP3K3, MAP3K1, MAP3K19 INSR 922/4885ALK 517/4885IGF1R 760/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.