Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12918516 | 0.84 | GRM5 (0.71) | GRM5RECQLACHEHPGDSMN1; SMN2 | |
| SCHEMBL22622324 | 0.81 | RECQL (0.66) | GRM5RECQLACHEHPGDSMN1; SMN2 | |
| SCHEMBL22622457 | 0.77 | NPC1 (0.73) | RECQLACHEHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL433828 | 0.77 | ACHE (0.81) | GRM5RECQLACHEHPGDSMN1; SMN2 | |
| SCHEMBL18166097 | 0.77 | ACHE (0.81) | GRM5RECQLACHEHPGDSMN1; SMN2 | |
| SCHEMBL25946040 | 0.77 | ACHE (0.81) | GRM5RECQLACHEHPGDSMN1; SMN2 | |
| SCHEMBL22622353 | 0.75 | RECQL (0.68) | GRM5RECQLACHEHPGDALDH1A1 | |
| SCHEMBL14297352 | 0.75 | KMT2A (0.62) | GRM5RECQLACHEHPGDALDH1A1 | |
| SCHEMBL14197786 | 0.75 | RECQL (0.82) | GRM5RECQLACHEHPGDALDH1A1 | |
| SCHEMBL14311713 | 0.75 | GRM5 (0.85) | GRM5RECQLHPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017091592-A1 | SUBSTITUTED BENZAMIDES USEFUL AS SODIUM CHANNEL BLOCKERS | GENENTECH, INC. (US) | 2017-06-01 | — | — | WO | disclosed |