Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21795445 | 0.77 | KDM4E (0.42) | JAK2JAK1JAK3KCNH2HRH3 | |
| SCHEMBL13411082 | 0.75 | TSHR (0.45) | EPHX2KMT2ALMNAALDH1A1NPC1 | |
| SCHEMBL24571244 | 0.75 | EPHX2 (0.40) | EPHX2JAK2JAK1JAK3LMNA | |
| SCHEMBL13411081 | 0.73 | LMNA (0.51) | EPHX2LMNAALDH1A1NPC1KDM4E | |
| SCHEMBL13411083 | 0.73 | EPHX2 (0.49) | EPHX2CYP1A2LMNAALDH1A1NPC1 | |
| SCHEMBL16235813 | 0.71 | EPHX2 (0.38) | EPHX2KMT2AALDH1A1KDM4E | |
| SCHEMBL1770819 | 0.71 | EPHX2 (0.38) | EPHX2KMT2AALDH1A1KDM4E | |
| SCHEMBL13411080 | 0.71 | EPHX2 (0.38) | EPHX2JAK2JAK1JAK3LMNA | |
| SCHEMBL3576015 | 0.71 | TP53 (0.35) | KCNH2HRH3LMNAALDH1A1CNR2 | |
| SCHEMBL3576010 | 0.71 | TP53 (0.35) | KCNH2HRH3LMNAALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3381913-B1 | 2-(((PYRROLIDIN-3-YL)CARBONYL)AMINO)-1H-IMIDAZOLE DERIVATIVES AS MELANOCORTIN RECEPTOR 1 (MCR1) AGONISTS FOR TREATING RHEUMATOID ARTHRITIS | MITSUBISHI TANABE PHARMA CORP (JP) | 2021-03-31 | — | — | EP | disclosed |
| WO-2017090743-A1 | NOVEL IMIDAZOLE COMPOUND AND USE THEREOF AS MELANOCORTIN RECEPTOR AGONIST | 田辺三菱製薬株式会社 | 2017-06-01 | — | — | WO | disclosed |