Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.86 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17783799 | 0.92 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL17783821 | 0.91 | ROCK2 (0.85) | ROCK2AAK1 | |
| SCHEMBL17783758 | 0.89 | ROCK2 (1.00) | ROCK2AAK1 | |
| SCHEMBL17783822 | 0.89 | ROCK2 (1.00) | ROCK2AAK1 | |
| SCHEMBL17783816 | 0.89 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL17783831 | 0.88 | ROCK2 (1.00) | ROCK2AAK1 | |
| SCHEMBL17783802 | 0.86 | ROCK2 (1.00) | ROCK2 | |
| SCHEMBL17783819 | 0.85 | ROCK2 (1.00) | ROCK2AAK1 | |
| SCHEMBL18917066 | 0.85 | ROCK2 (0.74) | ROCK2AAK1 | |
| SCHEMBL17783796 | 0.85 | ROCK2 (1.00) | ROCK2AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016950-B1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-06-07 | — | — | EP | claimed |