Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K3 | P46734 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.39 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.38 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22688920 | 0.83 | KDM4E (0.47) | SMN1; SMN2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29275431 | 0.81 | HSD17B10 (0.40) | MAP2K3LCKMAP2K6BTKMAP3K19 | |
| SCHEMBL3119349 | 0.79 | MAP2K3 (0.39) | MAP2K3MKNK1MKNK2NNMTSMN1; SMN2 | |
| SCHEMBL31408890 | 0.79 | MAP2K3 (0.42) | MAP2K3MKNK1MKNK2LIMK1IKBKB | |
| SCHEMBL3828963 | 0.79 | MAP2K3 (0.39) | MAP2K3LCKMAP2K6BTKMAP3K19 | |
| SCHEMBL15757457 | 0.79 | NOS2 (0.52) | MAP2K3LCKMAP2K6BTKMAP3K19 | |
| SCHEMBL3631556 | 0.79 | MAP2K3 (0.39) | MAP2K3LCKMAP2K6BTKMAP3K19 | |
| SCHEMBL21198627 | 0.76 | KDM4E (0.38) | MAP2K3LCKMAP2K6BTKMAP3K19 | |
| SCHEMBL21198626 | 0.76 | HSD17B10 (0.37) | MAP2K3MKNK1MKNK2LIMK1IKBKB | |
| SCHEMBL20579524 | 0.76 | MAP2K3 (0.40) | MAP2K3LCKMAP2K6BTKMAP3K19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922841-B1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2017-06-07 | — | — | EP | disclosed |