Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.38 |
| ▸ | KHK | P50053 | 3/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16145616 | 0.75 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNB4CHRNA3DPP4 | |
| SCHEMBL24528539 | 0.69 | CHRNB2 (0.49) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL25629014 | 0.68 | SOS1 (0.38) | SOS1DPP4 | |
| SCHEMBL14970402 | 0.66 | DPP4 (0.41) | SOS1DPP4 | |
| SCHEMBL30811775 | 0.66 | CHRNB2 (0.46) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL24528597 | 0.66 | CHRNB2 (0.46) | PTGS2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL19722756 | 0.65 | DPP4 (0.39) | SOS1DPP4 | |
| SCHEMBL5654734 | 0.63 | TACR3 (0.39) | SOS1KHKDPP4 | |
| SCHEMBL11963384 | 0.62 | CHRNB2 (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL11963225 | 0.62 | CHRNB2 (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763535-B1 | AZAINDOLES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2017-06-07 | — | — | EP | disclosed |