Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 1/20 | 0.59 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.49 |
| ▸ | MGLL | Q99685 | 6/20 | 0.49 |
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.49 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17513187 | 0.90 | VEGFA (0.59) | VEGFAEGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL4505464 | 0.89 | VEGFA (0.61) | VEGFAEGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL23434765 | 0.88 | VEGFA (0.57) | VEGFAEGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL15567036 | 0.88 | KMT2A (0.50) | VEGFAEGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL4298566 | 0.88 | VEGFA (0.52) | VEGFAEGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL28571957 | 0.87 | VEGFA (0.79) | VEGFAEGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL20137138 | 0.86 | VEGFA (0.61) | VEGFAEGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL15093855 | 0.86 | MGLL (0.59) | VEGFAEGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL20971874 | 0.85 | VEGFA (0.57) | VEGFAEGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL15093856 | 0.85 | VEGFA (0.57) | VEGFAEGLN1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017096045-A1 | MULTIVALENT RAS BINDING COMPOUNDS | KYRAS THERAPEUTICS, INC. (US) | 2017-06-08 | — | — | WO | disclosed |
| WO-2017096045-A1 | MULTIVALENT RAS BINDING COMPOUNDS | KYRAS THERAPEUTICS, INC. (US) | 2017-06-08 | — | — | WO | disclosed |
| US-20170158702-A1 | MULTIVALENT RAS BINDING COMPOUNDS | KYRAS THERAPEUTICS, INC. | 2017-06-08 | — | — | US | disclosed |
| US-20170158702-A1 | MULTIVALENT RAS BINDING COMPOUNDS | KYRAS THERAPEUTICS, INC. | 2017-06-08 | — | — | US | disclosed |
| US-20170158702-A1 | MULTIVALENT RAS BINDING COMPOUNDS | KYRAS THERAPEUTICS, INC. | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158702-A1 | MULTIVALENT RAS BINDING COMPOUNDS | KRAS, HRAS, NRAS | VEGFA 3269/4885EGLN1 3033/4885ALDH1A1 4640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.