Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 7/20 | 0.65 |
| ▸ | RPA1 | P27694 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MAP2 | P11137 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18943456 | 0.90 | MCL1 (0.59) | MCL1RPA1KDM4EMEN1ALDH1A1 | |
| SCHEMBL29569249 | 0.90 | MCL1 (0.59) | MCL1RPA1KDM4EMEN1ALDH1A1 | |
| SCHEMBL18919697 | 0.88 | MCL1 (0.78) | MCL1RPA1KDM4EMEN1ALDH1A1 | |
| SCHEMBL18943417 | 0.82 | MCL1 (0.68) | MCL1RPA1KDM4EMEN1ALDH1A1 | |
| SCHEMBL29568334 | 0.82 | MCL1 (0.68) | MCL1RPA1KDM4EMEN1ALDH1A1 | |
| SCHEMBL29568451 | 0.80 | MCL1 (0.65) | MCL1RPA1KDM4EMEN1ALDH1A1 | |
| SCHEMBL18942982 | 0.80 | MCL1 (0.65) | MCL1RPA1KDM4EMEN1ALDH1A1 | |
| SCHEMBL3611265 | 0.79 | MCL1 (1.00) | MCL1RPA1KDM4EMEN1ALDH1A1 | |
| SCHEMBL18919757 | 0.78 | MCL1 (0.75) | MCL1RPA1KDM4EMEN1ALDH1A1 | |
| SCHEMBL18943636 | 0.77 | MCL1 (0.94) | MCL1RPA1KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11439622-B2 | Inhibitors of metallo-beta-lactamases | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2022-09-13 | — | — | US | claimed |
| CN-108602795-B | Inhibitors of metallo-beta-lactamases | 牛津大学科技创新有限公司 | 2022-04-22 | — | — | CN | claimed |
| US-20200375946-A1 | INHIBITORS OF METALLO-BETA-LACTAMASES | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2020-12-03 | — | — | US | claimed |
| EP-3383858-A1 | INHIBITORS OF METALLO-BETA-LACTAMASES | Oxford University Innovation Limited (GB) | 2018-10-10 | — | — | EP | claimed |
| CN-108602795-A | The inhibitor of metal-beta-lactamase | 牛津大学科技创新有限公司 | 2018-09-28 | — | — | CN | claimed |
| WO-2017093727-A1 | INHIBITORS OF METALLO-BETA-LACTAMASES | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2017-06-08 | — | — | WO | claimed |
| CN-108602795-B | Inhibitors of metallo-beta-lactamases | 牛津大学科技创新有限公司 | 2022-04-22 | — | — | CN | disclosed |
| US-20200375946-A1 | INHIBITORS OF METALLO-BETA-LACTAMASES | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2020-12-03 | — | — | US | disclosed |
| WO-2017093727-A1 | INHIBITORS OF METALLO-BETA-LACTAMASES | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2017-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11439622-B2 | Inhibitors of metallo-beta-lactamases | IDO1, MGAM, LCT | MCL1 702/4885RPA1 4544/4885KDM4E 1800/4885 |
| US-20200375946-A1 | INHIBITORS OF METALLO-BETA-LACTAMASES | IDO1, MGAM, LCT | MCL1 702/4885RPA1 4544/4885KDM4E 1800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.