LCT

Lactase/phlorizin hydrolase · P09848 · LCT on Sugi Atlas →

2,934 patent compounds predicted against LCT, 1,276 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Nizubaglustat (SCHEMBL17132915)	1.00	12/20
SCHEMBL17132920	1.00	12/20
Nizubaglustat (SCHEMBL17132922)	1.00	12/20
Nizubaglustat (SCHEMBL17132924)	1.00	12/20
Nizubaglustat (SCHEMBL17132925)	1.00	12/20
SCHEMBL17132933	1.00	12/20
SCHEMBL17132966	1.00	12/20
SCHEMBL17132989	1.00	12/20
SCHEMBL17132990	1.00	12/20
SCHEMBL17133002	1.00	12/20
SCHEMBL17133010	1.00	12/20
SCHEMBL17132913	1.00	11/20
SCHEMBL17132918	1.00	11/20
SCHEMBL17132921	1.00	11/20
SCHEMBL17132926	1.00	11/20
SCHEMBL17132928	1.00	11/20
SCHEMBL17133000	1.00	11/20
SCHEMBL17133012	1.00	11/20
SCHEMBL17132948	0.81	11/20
SCHEMBL17132917	1.00	10/20

Clinical trials — most relevant to LCT by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
1 or 6 Months of Dual Antiplatelet Therapy After Drug-coated Balloon Angioplasty for De-novo Small Coronary Artery Disease	PHASE4	NOT_YET_RECRUITING
A Non-inferiority, Multicenter and Randomized, Single-Dose Study About a Treatment to Hypolactasia (LAILAI)	PHASE3	COMPLETED
Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Non-Erosive Gastroesophageal Reflux Disease (NERD)	PHASE3	UNKNOWN
Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Attention Deficit/Hyperactivity Disorder in Children	PHASE3	COMPLETED
Food Effect on PK of DW-1021 (Pelubiprofen 45 mg / Tramadol 45.9 mg) in Healthy Adults	PHASE1	RECRUITING
Phase 1 Clinical Trial to Evaluate the Effect of DWP14012 on the Pharmacokinetics of DWC202201 in Healthy Subjects	PHASE1	UNKNOWN
Ursodeoxycholic Acid for Rhegmatogenous Retinal Detachment	PHASE1	COMPLETED
A Study to Look at How GSK1325756 is Taken up by the Body When Given by Mouth When Stomach Acid is Reduced	PHASE1	COMPLETED
Clinical Study to Evaluate the Pharmacokinetics, Safety and Tolerability of CKD 371 in Healthy Subjects	PHASE1	COMPLETED
Study for Comparing The Pharmacokinetics of A Pregabalin Controlled Release Tablet 300mg With Immediate Release Formulation and to Assess the Effect of High Fat Diet in Healthy Male Subjects	PHASE1	COMPLETED
Diflucan Bioequivalence Study For Transferring The Manufacture	PHASE1	COMPLETED
The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION)	nan	NOT_YET_RECRUITING
Effect of an Polyphenolic Beverage in Healthy Volunteers	nan	ACTIVE_NOT_RECRUITING
Comparison of the Effectiveness of Oral Lactase Enzyme and Lactose Free Formula	nan	COMPLETED
Korean Post-marketing Surveillance for Xeljanz	nan	COMPLETED
Efficacy of a Probiotic Formulation in Adults With Lactose Intolerance and Methanogenic Intestinal Overgrowth	nan	COMPLETED
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Post Marketing Registry to Assess Usage, Safety and Effectiveness of Deltyba Tablets in Korean Patients With MDR-TB	nan	COMPLETED
Lactose Intolerance and Intestinal Permability	nan	ENROLLING_BY_INVITATION
Lactobreath: A Study to Diagnose Lactose Intolerance Using Breath Markers	nan	RECRUITING
Milk for Diabetes Prevention	nan	RECRUITING
Evaluation of GIMate Handheld Hydrogen Breath Monitor for Diagnosis of Lactose Malabsorption	nan	COMPLETED
Treatment Efficacy of Low FODMAP Versus Low Lactose Diet in IBS Patients	nan	COMPLETED
Prevalence of FODMAP Intolerance and JHS in FGID and Association With Microbiome, Dyssynergic Defecation and Dietary Intervention	nan	COMPLETED
Is the Expression of the GLUT5 Specific Fructose Transport Protein Abnormal in Patients With Fructose Intolerance?	nan	COMPLETED
Effect of SGLT2 Inhibitors on NAFLD in Type 2 Diabetic Patients with Diabetic Nephropathy	nan	NOT_YET_RECRUITING
The Effect of Probiotics on Lactose Intolerance	nan	COMPLETED
Effect OF Lactase Enzyme Supplements ON Intolerance IN Preterm Neonates	nan	RECRUITING
Samsca Post Marketing Surveillance Study	nan	COMPLETED
Association Between Lactase Deficiency, and the Small Intestinal Microbiome in Adults.	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a LCT binder may also engage these)

Protein	Name	Similarity
Q02401	—	1.000	Q02401 →
P09849	—	1.000	P09849 →
W5PLZ6	—	1.000	W5PLZ6 →
B9FHH2	—	0.994	B9FHH2 →
Q0DIT2	—	0.992	Q0DIT2 →
Q99N32	—	0.990	Q99N32 →
Q38786	—	0.990	Q38786 →
Q60HF6	—	0.990	Q60HF6 →
B6ZKM3	—	0.989	B6ZKM3 →
Q67XN2	—	0.988	Q67XN2 →
Q7XPY7	—	0.988	Q7XPY7 →
GLB1	Beta-galactosidase	0.987	landscape →
Q7XKV5	—	0.986	Q7XKV5 →
Q9FLU8	—	0.986	Q9FLU8 →
O65458	—	0.986	O65458 →
O82772	—	0.986	O82772 →
O80690	—	0.985	O80690 →
Q9Z218	—	0.985	Q9Z218 →
B3H5Q1	—	0.985	B3H5Q1 →
Q8GU20	—	0.985	Q8GU20 →
Q60DX8	—	0.985	Q60DX8 →
Q58D55	—	0.985	Q58D55 →
B7F8N7	—	0.984	B7F8N7 →
Q9BV94	—	0.984	Q9BV94 →
Q9SVS1	—	0.984	Q9SVS1 →
Q9SPP9	—	0.984	Q9SPP9 →
Q9ZP27	—	0.984	Q9ZP27 →
ERAP2	Endoplasmic reticulum aminopeptidase 2	0.984	landscape →
P23780	—	0.983	P23780 →
Q1XH04	—	0.983	Q1XH04 →