Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29948906 | 0.98 | CA2 (0.41) | CA2CA1PTPN1PTPN11PTGS1 | |
| SCHEMBL11335563 | 0.72 | MEN1 (0.52) | CA2PTGS1PTGS2SMN1; SMN2SLC22A12 | |
| SCHEMBL3265300 | 0.70 | CA2 (0.50) | CA2PTGS1PTGS2SLC22A12 | |
| SCHEMBL16389001 | 0.70 | TRIM24 (0.42) | CA2PTPN1PTPN11PTGS1PTGS2 | |
| SCHEMBL2449417 | 0.69 | RXFP1 (0.66) | SLC22A12KDM1A | |
| SCHEMBL16388979 | 0.69 | PTGS1 (0.40) | CA2PTPN1PTPN11PTGS1PTGS2 | |
| SCHEMBL18921160 | 0.69 | SLC22A12 (0.43) | CA2CA1PTPN1PTGS1PTGS2 | |
| SCHEMBL10044529 | 0.68 | RXFP1 (0.62) | PTGS1PTGS2SMN1; SMN2MEN1HTT | |
| SCHEMBL2489790 | 0.68 | PTGS1 (0.45) | CA2CA1PTGS1PTGS2SLC22A12 | |
| SCHEMBL31273419 | 0.68 | TDP1 (0.38) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3383868-A1 | ARYL SULFONAMIDES AS BLT1 ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2018-10-10 | — | — | EP | disclosed |
| WO-2017095724-A1 | ARYL SULFONAMIDES AS BLT1 ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-06-08 | — | — | WO | disclosed |