Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.48 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | MME | P08473 | 9/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21350792 | 0.90 | MME (0.50) | MMEACECTSL | |
| SCHEMBL19687827 | 0.90 | MME (0.51) | CTSSCTSKMMEACEATM | |
| SCHEMBL18922305 | 0.90 | MME (0.51) | CTSSCTSKMMEACEATM | |
| SCHEMBL19687828 | 0.90 | CTSS (0.49) | CTSSCTSKMMEACEATM | |
| SCHEMBL15474327 | 0.90 | CTSS (0.49) | CTSSCTSKMMEACEATM | |
| SCHEMBL15468114 | 0.88 | MME (0.58) | CTSSCTSKMMEACEATM | |
| SCHEMBL20681853 | 0.88 | MME (0.58) | CTSSCTSKMMEACEATM | |
| SCHEMBL11995841 | 0.84 | CTSS (0.53) | CTSSCTSKMMEACEATM | |
| SCHEMBL20681845 | 0.84 | MME (0.46) | MME | |
| SCHEMBL26380409 | 0.84 | MME (0.46) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670186-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-06-06 | — | — | US | disclosed |