Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Paritaprevir. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paritaprevir SCHEMBL25744892 | 1.00 | CTSB (0.45) | CTSBADRB3ADRA2BADRA2CCYP3A4 | |
| Paritaprevir SCHEMBL29359149 | 1.00 | CTSB (0.45) | CTSBADRB3ADRA2BADRA2CCYP3A4 | |
| Paritaprevir SCHEMBL3061958 | 1.00 | CTSB (0.45) | CTSBADRB3ADRA2BADRA2CCYP3A4 | |
| Paritaprevir SCHEMBL3061962 | 1.00 | CTSB (0.45) | CTSBADRB3ADRA2BADRA2CCYP3A4 | |
| Paritaprevir SCHEMBL3069969 | 1.00 | CTSB (0.45) | CTSBADRB3ADRA2BADRA2CCYP3A4 | |
| Paritaprevir SCHEMBL3069964 | 1.00 | CTSB (0.45) | CTSBADRB3ADRA2BADRA2CCYP3A4 | |
| Paritaprevir SCHEMBL18713503 | 1.00 | CTSB (0.45) | CTSBADRB3ADRA2BADRA2CCYP3A4 | |
| Paritaprevir SCHEMBL16541443 | 1.00 | CTSB (0.45) | CTSBADRB3ADRA2BADRA2CCYP3A4 | |
| Paritaprevir SCHEMBL19286688 | 1.00 | CTSB (0.45) | CTSBADRB3ADRA2BADRA2CCYP3A4 | |
| Paritaprevir SCHEMBL20145316 | 1.00 | CTSB (0.45) | CTSBADRB3ADRA2BADRA2CCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670205-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2017-06-06 | — | — | US | disclosed |