Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14426314 | 1.00 | HRH3 (0.97) | HRH3SLC6A3SIGMAR1L3MBTL1KDM4E | |
| SCHEMBL14426311 | 0.98 | HRH3 (1.00) | HRH3SLC6A3SIGMAR1L3MBTL1KDM4E | |
| SCHEMBL13148674 | 0.90 | HRH3 (0.79) | HRH3SLC6A3SIGMAR1L3MBTL1KDM4E | |
| SCHEMBL10196667 | 0.88 | HRH3 (0.81) | HRH3SLC6A3SIGMAR1L3MBTL1KDM4E | |
| SCHEMBL12880000 | 0.86 | HRH3 (0.78) | HRH3SLC6A3SIGMAR1L3MBTL1KDM4E | |
| SCHEMBL12879708 | 0.83 | HRH3 (0.73) | HRH3SLC6A3SIGMAR1SLC6A4POLB | |
| SCHEMBL30853791 | 0.83 | HRH3 (0.73) | HRH3SLC6A3SIGMAR1SLC6A4POLB | |
| SCHEMBL12021982 | 0.83 | HRH3 (0.73) | HRH3SLC6A3SIGMAR1L3MBTL1POLB | |
| SCHEMBL12854 | 0.82 | HRH3 (0.67) | HRH3KDM4E | |
| SCHEMBL29447423 | 0.82 | HRH3 (0.67) | HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670165-B2 | SIK inhibitor for use in a method of treating an inflammatory and/or immune disorder | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-06-06 | — | — | US | disclosed |