Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29447423 | 1.00 | HRH3 (0.67) | HRH3ALDH1A1SMN1; SMN2TDP1PRMT6 | |
| SCHEMBL31546411 | 0.98 | HRH3 (0.69) | HRH3ALDH1A1SMN1; SMN2TDP1PRMT6 | |
| SCHEMBL12981 | 0.98 | HRH3 (0.69) | HRH3ALDH1A1SMN1; SMN2TDP1PRMT6 | |
| SCHEMBL24495602 | 0.88 | HRH3 (0.57) | HRH3ALDH1A1SMN1; SMN2TDP1PRMT6 | |
| SCHEMBL26010164 | 0.86 | HRH3 (0.69) | HRH3ALDH1A1PRMT6KDM4EMAPT | |
| SCHEMBL11192726 | 0.86 | PRMT6 (0.78) | HRH3ALDH1A1SMN1; SMN2TDP1PRMT6 | |
| SCHEMBL11339852 | 0.86 | PRMT6 (0.78) | HRH3ALDH1A1SMN1; SMN2TDP1PRMT6 | |
| SCHEMBL20663301 | 0.84 | NCF1 (0.59) | HRH3ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL28849168 | 0.84 | CXCR4 (0.64) | HRH3ALDH1A1TDP1KDM4EMAPT | |
| SCHEMBL19206094 | 0.84 | ALDH1A1 (0.61) | HRH3ALDH1A1SMN1; SMN2TDP1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436446-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2023-06-07 | — | — | EP | disclosed |
| EP-1887008-B1 | THIENOTRIAZOLODIAZEPINE COMPOUND AND A MEDICINAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2021-04-21 | — | — | EP | disclosed |
| US-10975084-B2 | KDM5 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-04-13 | — | — | US | disclosed |
| EP-3203840-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2020-08-05 | — | — | EP | disclosed |
| US-20200048258-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| EP-3003314-B1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER | KALA PHARMACEUTICALS INC (US) | 2019-05-15 | — | — | EP | disclosed |
| EP-2791137-B1 | PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION PROCESS THEREFOR AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2019-01-23 | — | — | EP | disclosed |
| US-20180215719-A9 | SIK INHIBITOR FOR USE IN A METHOD OF TREATING AN INFLAMMATORY AND/OR IMMUNE DISORDER | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-08-02 | — | — | US | disclosed |
| EP-3141252-B1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMA (US) | 2018-07-25 | — | — | EP | disclosed |
| WO-2018053373-A1 | USES OF SATL-INDUCIBLE KINASE (SIK) INHIBITORS FOR TREATING OSTEOPOROSIS | THE GENERAL HOSPITAL CORPORATION (US) | 2018-03-22 | — | — | WO | disclosed |
| EP-0660667-B1 | INSECT REPELLENT COMPOSITIONS AND METHODS FOR USING SAME | INT FLAVORS & FRAGRANCES INC (US) | 1997-04-23 | — | — | EP | disclosed |
| US-5576010-A | Use of dimethyl substituted oxymethyl cyclohexane derivatives for their insect repellency properties | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1996-11-19 | — | — | US | disclosed |
| US-5521165-A | HETEROCYCLIC ORGANOBORON DERIVATIVES IN A POLYMER MATRIX | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1996-05-28 | — | — | US | disclosed |
| US-5472701-A | Used as soaps, candles for flies, mosquitoes; washing mammals | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1995-12-05 | — | — | US | disclosed |
| US-5464626-A | EXPOSING A THREE-DIMENSIONAL SPACE TO A SPECIFIED CARBONATE COMPOUND | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0660667-A1 | INSECT REPELLENT COMPOSITIONS AND METHODS FOR USING SAME. | INT FLAVORS & FRAGRANCES INC (US) | 1995-07-05 | — | — | EP | disclosed |
| US-5401500-A | House flies attracted with benzoin group and dimethyl benzyl carbinyl acetate | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0629344-A2 | Acyclic and carbocyclic ketones, alcohols, aldehydes nitriles and esters and uses thereof for their insect repellency and attractancy properties | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1994-12-21 | — | — | EP | disclosed |
| WO-1994006295-A1 | INSECT REPELLENT COMPOSITIONS AND METHODS FOR USING SAME | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1994-03-31 | — | — | WO | disclosed |
| US-5250575-A | Exposure to concentration in detergent or candle | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1993-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215719-A9 | SIK INHIBITOR FOR USE IN A METHOD OF TREATING AN INFLAMMATORY AND/OR IMMUNE DISORDER | SIK1, SIK2, SGK1 | HRH3 1246/4885ALDH1A1 4501/4885SMN1; SMN2 4328/4885 |
| US-20200048258-A1 | KDM5 INHIBITORS | KDM5A, KDM5B, KDM5C | HRH3 1440/4885ALDH1A1 1399/4885SMN1; SMN2 2028/4885 |
| US-10975084-B2 | KDM5 inhibitors | KDM5A, KDM5B, KDM5C | HRH3 1440/4885ALDH1A1 1399/4885SMN1; SMN2 2028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.