Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19594444 | 0.89 | PIK3CA (0.42) | PIK3CAPIK3CDMAP3K14 | |
| SCHEMBL1485581 | 0.85 | PIK3CA (0.43) | PIK3CAPIK3CDMAP3K14 | |
| SCHEMBL1485623 | 0.82 | PIK3CA (0.41) | PIK3CAPIK3CDMAP3K14 | |
| SCHEMBL1485171 | 0.80 | MAP3K14 (0.57) | PIK3CDMAP3K14 | |
| SCHEMBL12539370 | 0.78 | PIK3CA (0.45) | PIK3CAPIK3CDMAP3K14 | |
| SCHEMBL1528222 | 0.78 | PIK3CA (0.78) | PIK3CAPIK3CD | |
| SCHEMBL1485533 | 0.78 | PIK3CA (0.55) | PIK3CAPIK3CD | |
| SCHEMBL1485285 | 0.78 | PIK3CA (0.45) | PIK3CAPIK3CDMAP3K14 | |
| SCHEMBL12688777 | 0.78 | PIK3CA (0.56) | PIK3CAPIK3CD | |
| SCHEMBL12689287 | 0.78 | PIK3CD (0.51) | PIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670228-B2 | Benzoxazepin PI3K inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2017-06-06 | — | — | US | disclosed |