Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18923813 | 0.89 | PIK3CA (0.47) | PIK3CAPIK3CDMAP3K14 | |
| SCHEMBL1485431 | 0.85 | PIK3CA (0.39) | PIK3CAPIK3CDMAP3K14 | |
| SCHEMBL1485001 | 0.80 | MAP3K14 (0.54) | PIK3CDMAP3K14PIK3R1 | |
| SCHEMBL1485327 | 0.79 | PIK3CA (0.70) | PIK3CAPIK3CD | |
| SCHEMBL12539295 | 0.78 | PIK3CD (0.66) | PIK3CAPIK3CD | |
| SCHEMBL1485522 | 0.78 | ALPL (0.39) | PIK3CAPIK3CD | |
| SCHEMBL12690129 | 0.77 | MAP3K14 (0.44) | PIK3CDMAP3K14PIK3R1 | |
| SCHEMBL1528156 | 0.76 | PIK3CA (0.43) | PIK3CAPIK3CD | |
| SCHEMBL19594580 | 0.76 | PIK3CA (0.42) | PIK3CAPIK3CDMAP3K14PIK3R1 | |
| SCHEMBL1485528 | 0.75 | MAP3K14 (0.40) | PIK3CDMAP3K14PIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688891-B1 | BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2017-11-15 | — | — | EP | disclosed |