Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.53 |
| ▸ | FER | P16591 | 6/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.35 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20750840 | 1.00 | SYK (0.53) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL9103587 | 0.90 | SYK (0.57) | SYKFER | |
| SCHEMBL18925840 | 0.86 | SYK (0.52) | SYKFER | |
| SCHEMBL20750725 | 0.86 | SYK (0.52) | SYKFER | |
| SCHEMBL18925352 | 0.85 | SYK (0.73) | SYKFER | |
| SCHEMBL5028061 | 0.85 | SYK (0.73) | SYKFER | |
| SCHEMBL16130179 | 0.84 | SYK (0.51) | SYK | |
| SCHEMBL20750862 | 0.82 | SYK (0.42) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18925552 | 0.82 | SYK (0.42) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18925384 | 0.82 | SYK (0.42) | SYKFERMAPK3MAPK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |