Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20750725 | 1.00 | SYK (0.52) | SYKP2RX7PDE4BFER | |
| SCHEMBL2716337 | 0.90 | SYK (0.56) | SYKP2RX7PDE4B | |
| SCHEMBL20750824 | 0.89 | SYK (0.60) | SYKPDE4BFER | |
| SCHEMBL18925566 | 0.89 | SYK (0.60) | SYKPDE4BFER | |
| SCHEMBL20750755 | 0.86 | SYK (0.42) | SYKFER | |
| SCHEMBL18925384 | 0.86 | SYK (0.42) | SYKFER | |
| SCHEMBL20750840 | 0.86 | SYK (0.53) | SYKFER | |
| SCHEMBL18925516 | 0.86 | SYK (0.53) | SYKFER | |
| SCHEMBL18925339 | 0.85 | SYK (0.53) | SYKFER | |
| SCHEMBL18925576 | 0.85 | SYK (0.53) | SYKFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |