Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13961431 | 0.82 | BTK (0.52) | BTKGAAEPHX1 | |
| SCHEMBL18925569 | 0.82 | BTK (0.52) | BTKGAAEPHX1 | |
| SCHEMBL18928233 | 0.82 | BTK (0.52) | BTKGAAEPHX1 | |
| SCHEMBL21604197 | 0.77 | GAA (0.50) | BTKGAAEPHX1 | |
| SCHEMBL2544844 | 0.72 | BTK (0.48) | BTKGAAEPHX1 | |
| SCHEMBL1951353 | 0.72 | BTK (0.48) | BTKGAAEPHX1 | |
| SCHEMBL19790500 | 0.71 | BTK (0.39) | BTKGAAMAPK8EPHX1 | |
| SCHEMBL5027043 | 0.70 | MAPK8 (0.30) | MAPK8 | |
| SCHEMBL21166035 | 0.70 | IDH1 (0.31) | MAPK8 | |
| SCHEMBL20315450 | 0.70 | HRH3 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |