Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623461 | 0.81 | EPHX2 (0.36) | — | |
| SCHEMBL104840 | 0.76 | MAPK8 (0.31) | MAPK8 | |
| SCHEMBL21086571 | 0.72 | BTK (0.32) | — | |
| SCHEMBL25589867 | 0.71 | GAA (0.32) | — | |
| SCHEMBL18928233 | 0.70 | BTK (0.52) | — | |
| SCHEMBL18925569 | 0.70 | BTK (0.52) | — | |
| SCHEMBL13961431 | 0.70 | BTK (0.52) | — | |
| SCHEMBL18925565 | 0.70 | BTK (0.33) | MAPK8 | |
| SCHEMBL21166035 | 0.70 | IDH1 (0.31) | MAPK8 | |
| SCHEMBL19891744 | 0.69 | MAPK1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |