Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 19/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | FGR | P09769 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.36 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18925652 | 0.85 | SYK (0.54) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL20750820 | 0.85 | SYK (0.54) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL20750871 | 0.85 | SYK (0.54) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL18925830 | 0.83 | SYK (0.56) | SYKPRKCQKCNH2 | |
| SCHEMBL18925331 | 0.82 | SYK (0.43) | SYKKCNH2JAK2LCKLYN | |
| SCHEMBL9110145 | 0.81 | SYK (0.58) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL18926035 | 0.80 | SYK (0.56) | SYKPRKCQKCNH2JAK2LCK | |
| SCHEMBL20750751 | 0.79 | SYK (0.48) | SYK | |
| SCHEMBL18925605 | 0.79 | SYK (0.48) | SYK | |
| SCHEMBL2715579 | 0.78 | SYK (0.58) | SYKKCNH2JAK2LCKYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |