Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18925584 | 0.83 | SYK (0.47) | SYKKCNH2PRKCQ | |
| SCHEMBL18925663 | 0.81 | SYK (0.49) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925535 | 0.80 | SYK (0.65) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925816 | 0.80 | SYK (0.40) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925617 | 0.79 | SYK (0.62) | SYKKCNH2 | |
| SCHEMBL2726896 | 0.79 | SYK (0.76) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925609 | 0.78 | JAK1 (0.47) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL20750861 | 0.78 | SYK (0.56) | SYKKCNH2 | |
| SCHEMBL18926150 | 0.76 | SYK (0.47) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL20750820 | 0.74 | SYK (0.54) | SYKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |