Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.41 |
| ▸ | FER | P16591 | 6/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.37 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18925871 | 0.84 | SYK (0.43) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18925817 | 0.81 | SYK (0.54) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18925818 | 0.79 | SYK (0.47) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL20750741 | 0.79 | SYK (0.47) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18925872 | 0.79 | SYK (0.47) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18925816 | 0.78 | SYK (0.40) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18926198 | 0.78 | SYK (0.50) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18925390 | 0.78 | FER (0.56) | SYKFERMAPK3MAPK1KCNH2 | |
| SCHEMBL18926055 | 0.76 | CAMK1D (0.38) | SYKKCNH2AURKBCAMK1D | |
| SCHEMBL20750841 | 0.75 | SYK (0.34) | SYKFERJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |