Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10251443 | 0.83 | SYK (0.57) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925881 | 0.82 | SYK (0.46) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18926174 | 0.76 | SYK (0.49) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18926150 | 0.76 | SYK (0.47) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL5025937 | 0.75 | SYK (0.72) | SYK | |
| SCHEMBL14929573 | 0.75 | SYK (0.72) | SYK | |
| SCHEMBL14909157 | 0.75 | SYK (0.72) | SYK | |
| SCHEMBL20750824 | 0.73 | SYK (0.60) | SYKPDE4B | |
| SCHEMBL18925566 | 0.73 | SYK (0.60) | SYKPDE4B | |
| SCHEMBL2715648 | 0.72 | SYK (0.42) | SYKPDE4BMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |