Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18925663 | 0.80 | SYK (0.49) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL10254887 | 0.79 | SYK (0.58) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925609 | 0.77 | JAK1 (0.47) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925651 | 0.76 | SYK (0.49) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925816 | 0.76 | SYK (0.40) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925830 | 0.76 | SYK (0.56) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925516 | 0.73 | SYK (0.53) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL20750840 | 0.73 | SYK (0.53) | SYKKCNH2AURKBMAPK3MAPK1 | |
| SCHEMBL18925352 | 0.73 | SYK (0.73) | SYK | |
| SCHEMBL5028061 | 0.73 | SYK (0.73) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |