Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FER | P16591 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 14/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14908780 | 0.88 | SYK (0.58) | FERSYK | |
| SCHEMBL14929776 | 0.88 | SYK (0.58) | FERSYK | |
| SCHEMBL5027053 | 0.88 | SYK (0.58) | FERSYK | |
| SCHEMBL18925671 | 0.80 | FER (0.53) | FERSYKROCK2ROCK1 | |
| SCHEMBL19790806 | 0.79 | SYK (0.51) | FERSYKJAK2ROCK2ROCK1 | |
| SCHEMBL14909606 | 0.78 | SYK (0.56) | FERSYK | |
| SCHEMBL14909607 | 0.78 | SYK (0.56) | FERSYK | |
| SCHEMBL2729002 | 0.77 | SYK (0.56) | SYK | |
| SCHEMBL2728999 | 0.77 | SYK (0.56) | SYK | |
| SCHEMBL14923905 | 0.77 | ROCK2 (0.55) | FERSYKROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |