Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FER | P16591 | 10/20 | 1.00 |
| ▸ | SYK | P43405 | 10/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.67 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.67 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.67 |
| ▸ | CDC7 | O00311 | 1/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | PAK4 | O96013 | 1/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5025995 | 1.00 | FER (1.00) | FERSYKMAPK1MAPK3KCNH2 | |
| SCHEMBL18926052 | 0.86 | FER (0.75) | FERSYK | |
| SCHEMBL5027832 | 0.86 | FER (0.75) | FERSYK | |
| SCHEMBL14910185 | 0.86 | FER (1.00) | FERSYKMAPK1MAPK3KCNH2 | |
| SCHEMBL9106025 | 0.86 | FER (0.79) | FERSYKMAPK1MAPK3KCNH2 | |
| SCHEMBL14928519 | 0.86 | FER (0.79) | FERSYKMAPK1MAPK3KCNH2 | |
| SCHEMBL14929934 | 0.86 | FER (1.00) | FERSYKMAPK1MAPK3KCNH2 | |
| SCHEMBL14909796 | 0.86 | FER (0.79) | FERSYKMAPK1MAPK3KCNH2 | |
| SCHEMBL14910186 | 0.86 | FER (1.00) | FERSYKMAPK1MAPK3KCNH2 | |
| SCHEMBL5027032 | 0.85 | FER (0.74) | FERSYKKCNH2JAK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176154-A1 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |