Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 10/20 | 0.31 |
| ▸ | APP | P05067 | 6/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21654362 | 0.89 | BACE1 (0.39) | BACE1APPALDH1A1 | |
| SCHEMBL18562904 | 0.87 | BACE1 (0.41) | BACE1APP | |
| SCHEMBL21654400 | 0.83 | BACE1 (0.32) | BACE1APP | |
| SCHEMBL18927279 | 0.82 | BACE1 (0.31) | BACE1APP | |
| SCHEMBL945249 | 0.79 | CHRNA1 (0.37) | BACE1ALDH1A1 | |
| SCHEMBL18926447 | 0.74 | BACE1 (0.43) | BACE1APP | |
| SCHEMBL945466 | 0.74 | CHRNA1 (0.36) | BACE1 | |
| SCHEMBL19567276 | 0.72 | APP (0.38) | BACE1APP | |
| SCHEMBL18927263 | 0.70 | BACE1 (0.44) | BACE1APP | |
| SCHEMBL945271 | 0.69 | PARP1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176172-B1 | SPIROIMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS | ASTRAZENECA AB (SE) | 2020-01-29 | — | — | EP | disclosed |
| EP-3176172-A1 | SPIROIMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS | Astrazeneca AB (SE) | 2017-06-07 | — | — | EP | disclosed |