Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.44 |
| ▸ | APP | P05067 | 14/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18561593 | 0.86 | BACE1 (0.55) | BACE1APP | |
| SCHEMBL18926585 | 0.84 | BACE1 (0.59) | BACE1APPKCNH2BACE2 | |
| SCHEMBL18927140 | 0.83 | BACE1 (0.58) | BACE1APP | |
| SCHEMBL18927235 | 0.81 | BACE1 (0.41) | BACE1APPKCNH2BACE2 | |
| SCHEMBL932230 | 0.77 | BACE1 (0.59) | BACE1APPKCNH2BACE2 | |
| SCHEMBL18927162 | 0.73 | BACE1 (0.52) | BACE1APP | |
| SCHEMBL931281 | 0.73 | BACE1 (0.60) | BACE1APPKCNH2BACE2 | |
| SCHEMBL932626 | 0.72 | BACE1 (0.65) | BACE1APPKCNH2BACE2 | |
| SCHEMBL19566751 | 0.71 | APP (0.50) | BACE1APP | |
| SCHEMBL18927239 | 0.70 | LMNA (0.33) | BACE1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176172-B1 | SPIROIMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS | ASTRAZENECA AB (SE) | 2020-01-29 | — | — | EP | disclosed |
| EP-3176172-A1 | SPIROIMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS | Astrazeneca AB (SE) | 2017-06-07 | — | — | EP | disclosed |