Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 12/20 | 0.67 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17881870 | 0.80 | RIPK1 (1.00) | RIPK1POLBPRMT5WDR77LMNA | |
| SCHEMBL19471151 | 0.80 | RIPK1 (1.00) | RIPK1POLBPRMT5WDR77LMNA | |
| SCHEMBL18927573 | 0.78 | RIPK1 (0.61) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL18927572 | 0.77 | RIPK1 (0.59) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL18927446 | 0.75 | RIPK1 (0.50) | RIPK1 | |
| SCHEMBL17881970 | 0.74 | RIPK1 (0.71) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL24011067 | 0.74 | RIPK1 (0.68) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL17881976 | 0.73 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL27504373 | 0.73 | RIPK1 (0.66) | RIPK1 | |
| SCHEMBL17881984 | 0.73 | RIPK1 (1.00) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017096301-A1 | ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK 1) | DENALI THERAPEUTICS INC. (US) | 2017-06-08 | — | — | WO | disclosed |