Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 2/20 | 0.38 |
| ▸ | TLR1 | Q15399 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12317123 | 1.00 | TLR2 (0.38) | TLR2TLR1BCHECNR2TDP1 | |
| SCHEMBL31476207 | 1.00 | TLR2 (0.38) | TLR2TLR1BCHECNR2TDP1 | |
| SCHEMBL14180170 | 1.00 | TLR2 (0.38) | TLR2TLR1BCHECNR2TDP1 | |
| SCHEMBL30895423 | 1.00 | TLR2 (0.38) | TLR2TLR1BCHECNR2TDP1 | |
| SCHEMBL22443641 | 1.00 | TLR2 (0.38) | TLR2TLR1BCHECNR2TDP1 | |
| SCHEMBL25129444 | 1.00 | TLR2 (0.38) | TLR2TLR1BCHECNR2TDP1 | |
| SCHEMBL13228857 | 0.99 | TDP1 (0.38) | TLR2TLR1BCHECNR2TDP1 | |
| SCHEMBL25940770 | 0.92 | TDP1 (0.42) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL17589281 | 0.91 | CA12 (0.38) | TLR2TLR1BCHECNR2TDP1 | |
| SCHEMBL22687753 | 0.90 | BCHE (0.38) | BCHECNR2TDP1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170157265-A1 | ISOQUINOLIDINOBENZODIAZEPINES | CELLERANT THERAPEUTICS, INC. | 2017-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170157265-A1 | ISOQUINOLIDINOBENZODIAZEPINES | BCR, IGLV6-57, GABRA4 | TLR2 2855/4885TLR1 4226/4885BCHE 698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.