Sugi Predict

Sugi Predict / Targets / GABRA4

GABRA4

Gamma-aminobutyric acid receptor subunit alpha-4 · P48169 · GABRA4 on Sugi Atlas →

129,079 patent compounds predicted against GABRA4, 67,373 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL15406 SCHEMBL15406 0.61 20/20
Fipronil Fipronil (SCHEMBL15088) 0.59 20/20
SCHEMBL41972 SCHEMBL41972 0.59 20/20
Fipronil Fipronil (SCHEMBL44222) 0.59 20/20
Ethiprole Ethiprole (SCHEMBL27048) 0.56 20/20
SCHEMBL25897 SCHEMBL25897 0.51 20/20
SCHEMBL33214 SCHEMBL33214 0.52 19/20
SCHEMBL26584 SCHEMBL26584 0.51 19/20
SCHEMBL9107 SCHEMBL9107 0.56 12/20
SCHEMBL8532 SCHEMBL8532 1.00 11/20
SCHEMBL9035 SCHEMBL9035 0.56 10/20
SCHEMBL8632 SCHEMBL8632 0.54 10/20
SCHEMBL8670 SCHEMBL8670 0.57 9/20
SCHEMBL8856 SCHEMBL8856 0.53 9/20
SCHEMBL9273 SCHEMBL9273 0.53 9/20
SCHEMBL8931 SCHEMBL8931 0.51 9/20
SCHEMBL8932 SCHEMBL8932 0.51 9/20
SCHEMBL9163 SCHEMBL9163 0.58 8/20
SCHEMBL8941 SCHEMBL8941 0.54 8/20
Bretazenil Bretazenil (SCHEMBL124595) 0.69 7/20

Clinical trials — most relevant to GABRA4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Computational Assessment of GABA Receptor Modulation in PTSD PHASE4RECRUITING
Safety of Ramelteon in Elderly Subjects PHASE4COMPLETED
Attenuate the Stress Response in Laparoscopic Cholecystectomy PHASE4NOT_YET_RECRUITING
The Effects of Levetiracetam on Alcohol Dependent Subjects PHASE4COMPLETED
Bispectral Index-guided Sedation for Flexible Bronchoscopy PHASE4COMPLETED
Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery PHASE4RECRUITING
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia PHASE3COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia PHASE2COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia PHASE2COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy PHASE1/PHASE2WITHDRAWN
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome PHASE2RECRUITING
PET Imaging of Brain Peripheral Benzodiazepine Receptors PHASE1COMPLETED
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28 PHASE1COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T EARLY_PHASE1UNKNOWN
MEG Study of Acute STX209 Effects in ASD EARLY_PHASE1COMPLETED
GABA Biomarkers in Dravet Syndrome nanRECRUITING
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy nanENROLLING_BY_INVITATION
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy nanUNKNOWN
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. nanCOMPLETED
Remifentanil and Remimazolam to Limit Patient Movement nanRECRUITING
Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk nanCOMPLETED
GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA) nanCOMPLETED
Assessment of Peripheral GABA Receptors for Local Pain Relief nanUNKNOWN
Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain nanRECRUITING
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory nanCOMPLETED
Brain Changes in Patients With Focal Hand Dystonia nanCOMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Effects of Flumazenil on Brain Excitability nanCOMPLETED
Functional Study of Inhibitory Neurotransmission in the Human Epileptic Brain. nanRECRUITING
Phenobarbital Versus Levetiracetam Neonatal Convulsion nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a GABRA4 binder may also engage these)

ProteinNameSimilarity
P20237 — 1.000 P20237 →
Q9D6F4 — 1.000 Q9D6F4 →
P28471 — 1.000 P28471 →
Q90845 — 0.970 Q90845 →
GABRA6 Gamma-aminobutyric acid receptor subunit alpha-6 0.964 landscape →
P10064 — 0.962 P10064 →
P26049 — 0.961 P26049 →
Q08832 — 0.960 Q08832 →
P20236 — 0.959 P20236 →
P16305 — 0.957 P16305 →
GABRA3 Gamma-aminobutyric acid receptor subunit alpha-3 0.956 landscape →
P30191 — 0.955 P30191 →
P50572 — 0.951 P50572 →
P24045 — 0.949 P24045 →
GABRR1 Gamma-aminobutyric acid receptor subunit rho-1 0.948 landscape →
Q68RJ7 — 0.945 Q68RJ7 →
GABRR2 Gamma-aminobutyric acid receptor subunit rho-2 0.945 landscape →
Q9PTS8 — 0.944 Q9PTS8 →
P56475 — 0.944 P56475 →
P47742 — 0.943 P47742 →
P26714 — 0.941 P26714 →
Q0II76 — 0.941 Q0II76 →
P56476 — 0.939 P56476 →
GABRR3 Gamma-aminobutyric acid receptor subunit rho- 0.937 landscape →
P50573 — 0.936 P50573 →
SLC12A2 Solute carrier family 12 member 2 0.935 landscape →
Q61143 — 0.933 Q61143 →
P43144 — 0.932 P43144 →
Q9DA37 — 0.931 Q9DA37 →
CHRNA9 Neuronal acetylcholine receptor subunit alpha-9 0.931 landscape →