Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EBP | Q15125 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14871535 | 1.00 | KDM4E (0.48) | KDM4EHTTLMNAGAATDP1 | |
| SCHEMBL12283959 | 0.84 | KDM4E (0.44) | KDM4EHTTLMNAGAATDP1 | |
| SCHEMBL18930552 | 0.83 | KDM4E (0.49) | KDM4EHTTLMNAGAATDP1 | |
| SCHEMBL12280826 | 0.81 | HDAC6 (0.43) | KDM4EHTTLMNAGAATDP1 | |
| SCHEMBL2549392 | 0.79 | KDM4E (0.51) | KDM4EHTTLMNAGAATDP1 | |
| SCHEMBL578434 | 0.78 | KDM4E (0.40) | KDM4EHTTLMNAGAATDP1 | |
| SCHEMBL578435 | 0.78 | KDM4E (0.40) | KDM4EHTTLMNAGAATDP1 | |
| SCHEMBL578436 | 0.78 | KDM4E (0.40) | KDM4EHTTLMNAGAATDP1 | |
| SCHEMBL578437 | 0.78 | KDM4E (0.40) | KDM4EHTTLMNAGAATDP1 | |
| SCHEMBL12383 | 0.78 | ALDH1A1 (0.55) | KDM4EHTTLMNAGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556070-B1 | SYNTHESIS OF CHIRAL 2-(1H-INDAZOL-6-YL)-SPIRO[CYCLOPROPANE-1,3'- INDOLIN]-2'-ONES | UNIV HEALTH NETWORK (CA) | 2017-06-07 | — | — | EP | disclosed |