Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 10/20 | 0.44 |
| ▸ | CETP | P11597 | 4/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3553343 | 0.83 | TACR1 (0.43) | TACR1CETPSERPINE1TRPM8EPHX1 | |
| SCHEMBL3554374 | 0.82 | TACR1 (0.42) | TACR1CETPSERPINE1TRPM8 | |
| SCHEMBL5148340 | 0.81 | TACR1 (0.41) | TACR1CETPSERPINE1 | |
| SCHEMBL1896131 | 0.78 | TACR1 (0.39) | TACR1CETPSERPINE1TRPM8EPHX1 | |
| SCHEMBL3729587 | 0.76 | TACR1 (0.43) | TACR1CETP | |
| SCHEMBL4183431 | 0.76 | CETP (0.67) | CETP | |
| SCHEMBL3729637 | 0.76 | CETP (0.62) | CETP | |
| SCHEMBL3554917 | 0.74 | CETP (0.61) | CETP | |
| SCHEMBL5147175 | 0.74 | TACR1 (0.46) | TACR1SERPINE1 | |
| SCHEMBL3551798 | 0.73 | CETP (0.49) | TACR1CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193365-B2 | CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-06-05 | — | — | US | disclosed |
| US-7935727-B2 | CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-05-03 | — | — | US | disclosed |
| US-20100249024-A1 | CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20090124689-A1 | CETP Inhibitors | MERCK SHARP & DOHME CORP. | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249024-A1 | CETP INHIBITORS | CETP, APOB, NPC1 | TACR1 3645/4885CETP 1/4885MDM2 3889/4885 |
| US-20090124689-A1 | CETP Inhibitors | CETP, APOB, MTTP | TACR1 3027/4885CETP 1/4885MDM2 2617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.