Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 20/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | TACR1 | P25103 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17309177 | 1.00 | GLS (0.61) | GLSSLC6A2TACR1OPRM1HTR2B | |
| SCHEMBL22193580 | 0.93 | GLS (0.53) | GLSSLC6A2TACR1OPRM1HTR2B | |
| SCHEMBL18890098 | 0.82 | GLS (0.59) | GLS | |
| SCHEMBL18951919 | 0.82 | GLS (0.59) | GLS | |
| SCHEMBL18890107 | 0.81 | GLS (0.58) | GLS | |
| SCHEMBL17309281 | 0.81 | GLS (0.55) | GLS | |
| SCHEMBL18933721 | 0.81 | GLS (0.58) | GLS | |
| SCHEMBL18890324 | 0.80 | GLS (0.57) | GLSSLC6A2TACR1OPRM1HTR2B | |
| SCHEMBL29543664 | 0.80 | GLS (0.57) | GLSSLC6A2TACR1OPRM1HTR2B | |
| SCHEMBL17309207 | 0.80 | GLS (0.58) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148994-B1 | 1, 3, 4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017093299-A1 | 1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-06-08 | — | — | WO | disclosed |