Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4495254 | 0.79 | PTPN1 (0.42) | MEN1KMT2ACRHBPCRHR2MAPT | |
| SCHEMBL16372305 | 0.75 | CMA1 (0.40) | BRD4MAPTRXFP1ALDH1A1GAA | |
| SCHEMBL15826628 | 0.75 | CMA1 (0.40) | BRD4MAPTRXFP1ALDH1A1GAA | |
| SCHEMBL4867889 | 0.72 | SMN1; SMN2 (0.43) | BRD4MAPTLMNARAB9AALDH1A1 | |
| SCHEMBL4866466 | 0.72 | SMN1; SMN2 (0.43) | BRD4MAPTLMNARAB9AALDH1A1 | |
| SCHEMBL4496967 | 0.70 | P2RY1 (0.40) | MEN1KMT2AMAPTMAPK1LMNA | |
| SCHEMBL4498465 | 0.70 | MAPK1 (0.38) | MEN1KMT2AMAPTMAPK1LMNA | |
| SCHEMBL4870374 | 0.68 | SMN1; SMN2 (0.43) | BRD4MAPTLMNARAB9AALDH1A1 | |
| SCHEMBL30977968 | 0.66 | BRD4 (0.55) | BRD4 | |
| SCHEMBL3855280 | 0.66 | ALDH1A1 (0.45) | MEN1KMT2ACRHBPCRHR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019493-B1 | MODIFIED BET-PROTEIN INHIBITING DIHYDROCHINOXALINONES AND DIHYDROPYRIDOPYRAZINONES | Bayer Pharma AG (DE) | 2017-06-14 | — | — | EP | disclosed |