Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 7/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 5/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12495603 | 0.88 | MAPK1 (0.48) | ATRMAPKAPK2MAPK1GRM5PARP10 | |
| SCHEMBL12496236 | 0.87 | GABRG2 (0.47) | ATRMAPKAPK2MAPK1GRM5PARP10 | |
| SCHEMBL18937006 | 0.83 | MAP4K4 (0.50) | MAPKAPK2MAPK1GRM5PARP10PARP11 | |
| SCHEMBL12077884 | 0.80 | KCNH2 (0.44) | ATRMAPK1 | |
| SCHEMBL18937013 | 0.78 | MAPK1 (0.40) | ATRMAPK1 | |
| SCHEMBL12495496 | 0.77 | MAPK1 (0.44) | ATRMAPKAPK2MAPK1GRM5PARP10 | |
| SCHEMBL27946388 | 0.77 | MAPK1 (0.49) | MAPKAPK2MAPK1PARP10PARP11 | |
| SCHEMBL12495198 | 0.76 | MAPK1 (0.47) | ATRMAPKAPK2MAPK1GRM5PARP10 | |
| SCHEMBL12077111 | 0.75 | MAPK1 (0.44) | ATRMAPKAPK2MAPK1PARP10PARP11 | |
| SCHEMBL12077344 | 0.75 | MAPK1 (0.44) | ATRMAPKAPK2MAPK1PARP10PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-B1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |