Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.40 |
| ▸ | HTR2C | P28335 | 12/20 | 0.40 |
| ▸ | ATR | Q13535 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12077869 | 0.84 | MAPK1 (0.46) | ATRKCNH2CCNT1CDK4CCNA2 | |
| SCHEMBL12495193 | 0.83 | MAPK1 (0.41) | ATRKCNH2 | |
| SCHEMBL18937019 | 0.83 | ATR (0.40) | HTR2AHTR2CATRKCNH2L3MBTL1 | |
| SCHEMBL12495170 | 0.82 | MAPK1 (0.45) | ATRKCNH2 | |
| SCHEMBL18112982 | 0.82 | PRF1 (0.40) | HTR2AHTR2CLRRK2KCNH2 | |
| SCHEMBL12495789 | 0.80 | KCNH2 (0.39) | ATRKCNH2 | |
| SCHEMBL18936978 | 0.79 | MAPK1 (0.44) | ATRKCNH2 | |
| SCHEMBL12077335 | 0.79 | ADRB2 (0.41) | HTR2AHTR2CATRLRRK2KCNH2 | |
| SCHEMBL18936982 | 0.78 | KCNH2 (0.41) | ATRKCNH2 | |
| SCHEMBL18936981 | 0.77 | KCNH2 (0.39) | HTR2AHTR2CATRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-B1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |