Acetylcarnitine

Acetylcarnitine

SCHEMBL1893949

CC(=O)OC(CC(=O)[O-])C[N+](C)(C)C.C[N+](C)(C)CC(O)CC(=O)[O-]

nearest known ligand 0.87

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.87
KMT2A Q03164 3/20 0.87
CYP1A2 P05177 1/20 0.87
HRH1 P35367 1/20 0.87
SLC22A16 Q86VW1 1/20 0.67
CYP2C19 P33261 2/20 0.61
RECQL P46063 1/20 0.61
SMN1; SMN2 Q16637 2/20 0.60
LMNA P02545 1/20 0.60
SLC25A20 O43772 3/20 0.52
TSHR P16473 3/20 0.52
MAPT P10636 3/20 0.52
TP53 P04637 2/20 0.52
CYP2D6 P10635 2/20 0.52
SLC6A5 Q9Y345 2/20 0.52
KDM4E B2RXH2 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2C9 P11712 1/20 0.52
NFKB1 P19838 1/20 0.52
THPO P40225 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetylcarnitine SCHEMBL7139430 1.00 MEN1 (0.87) MEN1KMT2ACYP1A2HRH1SLC22A16
Acetylcarnitine SCHEMBL1893948 0.98 MEN1 (0.84) MEN1KMT2ACYP1A2HRH1SLC22A16
Acetylcarnitine SCHEMBL677128 0.93 MEN1 (1.00) MEN1KMT2ACYP1A2HRH1SLC22A16
Acetylcarnitine SCHEMBL118455 0.93 MEN1 (1.00) MEN1KMT2ACYP1A2HRH1SLC22A16
Acetylcarnitine SCHEMBL28017793 0.93 MEN1 (1.00) MEN1KMT2ACYP1A2HRH1SLC22A16
Acetylcarnitine SCHEMBL69781 0.93 MEN1 (1.00) MEN1KMT2ACYP1A2HRH1SLC22A16
Acetylcarnitine SCHEMBL951660 0.91 MEN1 (0.96) MEN1KMT2ACYP1A2HRH1SLC22A16
Acetylcarnitine SCHEMBL9300885 0.91 MEN1 (0.96) MEN1KMT2ACYP1A2HRH1SLC22A16
Acetylcarnitine SCHEMBL4378230 0.91 MEN1 (0.96) MEN1KMT2ACYP1A2HRH1SLC22A16
Acetylcarnitine SCHEMBL387375 0.91 MEN1 (0.96) MEN1KMT2ACYP1A2HRH1SLC22A16

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230130325-A1 SERUM METABOLITES AS BIOMARKERS FOR CARNITINE TREATMENT OF SEPSIS THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER 2023-04-27 US disclosed
WO-2021202608-A1 SERUM METABOLITES AS BIOMARKERS FOR CARNITINE TREATMENT OF SEPSIS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2021-10-07 WO disclosed
US-10330685-B2 Markers for sepsis treatment THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2019-06-25 US disclosed
EP-2729491-B1 BIOLOGICAL METHODS FOR PREPARING A FATTY DICARBOXYLIC ACID RADICI CHIMICA S P A (IT) 2019-05-08 EP disclosed
US-20170247709-A1 EUKARYOTIC ORGANISMS AND METHODS FOR INCREASING THE AVAILABILITY OF CYTOSOLIC ACETYL-COA, AND FOR PRODUCING 1,3-BUTANEDIOL GENOMATICA, INC. 2017-08-31 US disclosed
US-20170052192-A1 MARKERS FOR SEPSIS TREATMENT THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2017-02-23 US disclosed
EP-2935563-A2 BIOLOGICAL METHODS FOR PREPARING A FATTY DICARBOXYLIC ACID Verdezyne, Inc. (US) 2015-10-28 EP disclosed
US-20140322779-A1 EUKARYOTIC ORGANISMS AND METHODS FOR INCREASING THE AVAILABILITY OF CYTOSOLIC ACETYL-COA, AND FOR THE PRODUCING 1,3-BUTANEDIOL GENOMATICA, INC. 2014-10-30 US disclosed
WO-2014100461-A2 BIOLOGICAL METHODS FOR PREPARING A FATTY DICARBOXYLIC ACID VERDEZYNE, INC. (US) 2014-06-26 WO disclosed
WO-2013071226-A1 EUKARYOTIC ORGANISMS AND METHODS FOR INCREASING THE AVAILABILITY OF CYTOSOLIC ACETYL-COA, AND FOR PRODUCING 1,3-BUTANEDIOL GENOMATICA, INC. (US) 2013-05-16 WO disclosed
US-6335361-B1 Method of treating benign forgetfulness JUVENON INC. 2002-01-01 US disclosed
US-20010043983-A1 Nutritional supplements for aged pets HAMILTON NATHAN D (US) 2001-11-22 US disclosed
EP-1039894-B1 COMPOSITIONS FOR INCREASING THE CONCENTRATION AND/OR MOTILITY OF SPERMATOZOA IN HUMANS SIGMA TAU HEALTHSCIENCE SPA (IT) 2001-10-17 EP disclosed
US-20010018455-A1 Medicament and therapeutical method for treating idiopathic asthenozoospermia SIGMA-TAU HEALTHSCIENCE, S.P.A. (IT) 2001-08-30 US disclosed
WO-2001058271-A1 NUTRITIONAL SUPPLEMENTS FOR AGED PETS JUVENON, INC. (US) 2001-08-16 WO disclosed
US-6235784-B1 SEXUAL DISORDERS SIGMA-TAU HEALTHSCIENCE S.P.A. (IT) 2001-05-22 US disclosed
WO-2001032168-A1 METHOD OF TREATING BENIGN FORGETFULNESS JUVENON, INC. (US) 2001-05-10 WO disclosed
WO-2001021208-A1 NUTRITIONAL SUPPLEMENT FOR INCREASED ENERGY AND STAMINA JUVENON CORPORATION (US) 2001-03-29 WO disclosed
US-6090848-A SYNERGISTIC MIXTURE OF CARNITINE AND ACETYLCARNITINE SIGMA-TAU HEALTHSCIENCE S.P.A. (IT) 2000-07-18 US disclosed
US-5863940-A Medicament and therapeutical method for treating idiopathic asthenozoospermia SIGMA-TAU HEALTHSCIENCE S.P.A. (IT) 1999-01-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10330685-B2 Markers for sepsis treatment CPT2, SLC25A20, CRAT MEN1 4760/4885KMT2A 2914/4885CYP1A2 3573/4885
US-20170052192-A1 MARKERS FOR SEPSIS TREATMENT CPT2, SLC25A20, CRAT MEN1 4760/4885KMT2A 2914/4885CYP1A2 3573/4885
US-20230130325-A1 SERUM METABOLITES AS BIOMARKERS FOR CARNITINE TREATMENT OF SEPSIS CPT2, SLC25A20, CRAT MEN1 4445/4885KMT2A 1455/4885CYP1A2 2706/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.